Was having trouble with my ESC key in Vista ( 64 bit ), it simply wasn't working in aps it was supposed to work in, the way it was supposed to work. It never worked for cancel and in Photoshop, that's a big deal.
Having searched the web I found that the only related information was the suggestion to "turn off the ease of access controls" and turn off "sticky keys" (if this is your problem, go there first.) Having hated those little dohickeys for a while they were already off. So I needed another solution.
The last thing I'd done, just before this started happening was I had installed the old Graphire 4 tablet and the latest software from Wacom.
I uninstalled the software, rebooted and lo and behold! my esc key started working again.
I called Wacom in the off chance that their tech support would help a guy with two year old refurbished tablet. Sure enough I got a fellow named Joe who was very helpful. He had me take the plastic shell off the tablet and also deactivate "Tablet PC Input Service" in the Services control of Computer management:
Right click on My Computer
Select Services & Applications
Scroll to Tablet PC Input Service, disable it and stop it.
Keep in mind this MIGHT disable some services you want to keep if you have a Tablet PC.
Joe also asked me to take the plastic cover off the wacom tablet and reinstall the software.
After installation, the ESC key still functioned. Joe thinks it was the plastic cover pressing down on one of the buttons... I'm not so sure.
Joe also suggested I try using the pen for a few days without using the mouse. He felt I'd never go back... we'll see. :)
In the end, the ESC key now functions again and Wacom has proven itself to be a company with great customer support. Thanks Joe!